Episode 1001

The first episode of Season 10, and the two hundred and twentieth episode episode of America's Got Talent overall, aired on May 26, 2006. It was the first auditions episode and took place in TBA. auditions episode and took place in Los Angeles. TBD acts from this episode proceeded to the next round, and TBD acts were rejected. The judges' decisions for TBD acts were never revealed.

Howard Stern, Heidi Klum, Mel B, and Howie Mandel all returned as judges (this panel's third consecutive season). Nick Cannon returned as host for his seventh season.